Peptides derived from Royal Jelly induce gastric cancer cells apoptosis by cell cycle arresting
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Author(s)
Abstract
Functions of Royal jelly polysaccharide have been widely explored, yet, the anti-tumor potency of Royal jelly peptides (RJPs) has never been explored. However, the anti-tumor property of RJPs was rarely explored. The present study evaluated the in vitro effects of RJPs on human gastric cancer cell lines. We found that RJP-1 (SHGEWL) significantly inhibited the proliferation of the MKN-45 cells in a does- and time-dependent manner. Further study revealed that RJP-1 regulated the p53/MDM2 state and blocked the cell cycle in the G0/G1 phase, which accompanied with inhibiting the CDK2, 4 and cyclin D, E expressions. In addition, RJP-1 significantly increased the Bax/Bcl-2 ratio and activated the Caspases, thereby inducing the MKN-45 cell apoptosis. The current findings reveal that the boiactive peptides in the Royal jelly maybe shining anti-cancer agents.
Keywords
Royal jelly; Gstric cancer; Cell cycle arrest, Apoptosis
Cite this paper
Jie Liu, Huailing Wang, Xiaowei Zeng, Xizhuo Sun, Zhendan He, Liteng Yang, Shuqi Qiu, Lin Mei,
Peptides derived from Royal Jelly induce gastric cancer cells apoptosis by cell cycle arresting
, SCIREA Journal of Medicine.
Volume 4, Issue 1, February 2020 | PP. 10-30.
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