HLA-B27 antigen in spondyloarthritis in sub-Saharan Africa: the example of Senegal.
DOI: 188 Downloads 4669 Views
Author(s)
Abstract
Objective. The aim of this study is to evaluate the presence of the HLA-B27 antigen in SpA in Senegalese hospitals. Patients and method: This is a retrospective study carried out in the rheumatology department of the CHU Le Dantec in Dakar between January 2012 and January 2017. The diagnosis of spondyloarthritis was retained, in accordance with the criteria of Assessment of Spondyloarthrisis and New York modified. For each patient, the following data were collected: age, sex, time to diagnosis, type of SpA, HLA B27 phenotyping. Results: We collected 209 observations of spondyloarthritis with a mean age of 46 years (extremes 20 and 66 years), 137 (65.6%) were women. The mean time to diagnosis was 5 years. Axial involvement was lumbar for 180 cases (86%). HLA-B 27 phenotyping was performed in all patients, 108 patients were HLA-B 27 positive (51.7%). These patients were slightly younger with a mean age of 38 years (extremes 20 and 55 years). Among the 108 HLA-B27 positive patients, 53/109 (48.6%) were from the Peulh (Fula) ethnic group. An AS was found in 88/109 cases (80.7%) and all patients with uveitis were HLA-B27 positive. Conclusion: Spondyloarthritis is growing in Senegalese hospitals. They mainly affect women and the HLA-27 antigen is present in half of the cases.
Keywords
Spondyloarthritis, HLA-B27, Senegal
Cite this paper
Kaba Condé, Hugues Ghislain Atakla, Mahaman Salissou Garba, Moustapha Niasse, Rama Diallo, Coumba Diouf, Saïdou Diallo,
HLA-B27 antigen in spondyloarthritis in sub-Saharan Africa: the example of Senegal.
, SCIREA Journal of Medicine.
Volume 4, Issue 4, August 2020 | PP. 69-76.
References
[ 1 ] | Wang R, Ward MM. Epidemiology of axial spondyloarthritis: an update. Curr Opin Rheumatol. 2018; 30: 137-143. |
[ 2 ] | Sieper J, Braun J, Dougados M, Baeten D. Axial spondyloarthritis. Nat Rev Dis Primers. 2015; 9;1:15013 |
[ 3 ] | Dean LE, Jones GT, Macdonald AG, Downham C, Sturrock RD, Macfarlane GJ. Global prevalence of ankylosing spondylitis. Rheumatology (Oxford). 2014: 2014; 53:650–7. |
[ 4 ] | Cao K, Moormann AM, Lyke KE, et al. Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci. Tissue Antigens. 2004; 63:293–325. |
[ 5 ] | Moustafa M, Owonayo O, Khan MA. (2000). Spondyloarthropathies in sub-Saharan Africa. Curr Opin Rheumatol. 12:281–6. |
[ 6 ] | Jeandell P, Roux H. Épidémiologie des affections rhumatologiques en Afrique subsaharienne. Revue du Rhumatisme. 2002. 69: 764-76 |
[ 7 ] | Bileckot R, Mouaya A, Makuwa M. Prevalence and clinical presentations Spondylitis. Bull Soc Pathol Exot. 2003; 96:21–3. |
[ 8 ] | Maharaj AB, Govender J, Maharaj K, Rajkaran M, Tak PP. Summary of Sensitivity and Specificity for Psoriatic Arthritis in a South African Cohort according to Classification Criteria. Journal of Rheumatology. 2015; 42: 960-962 |
[ 9 ] | Mijiyawa M. Spondyloarthropathies in patients attending the rheumatology unit of Lomé hospital. J Rheumatol. 1993; 20:1167–9. |
[ 10 ] | Njobvu P, McGill P, Kerr H, Jellis J, Pobee J. Spondyloarthropathy and human immunodeficiency virus infection in Zambia. J Rheumatol.1998; 25:15539. |
[ 11 ] | Tikly M, Njobvu P, McGill P. (2014). Spondyloarthritis in sub-Saharan Africa. Curr Rheumatol Rep. 16:421. |
[ 12 ] | Belachew D-A, Sandu N, Schaller B, Guta Z. Ankylosing spondylitis in sub-Saharan Africa.Postgrad Med J. 2009 ;85:353–357. |
[ 13 ] | Brown MA, Jepson A, Young A, et al. Ankylosing spondylitis in West Africans: evidence for non-HLA B27 protective effect. Ann Rheum Dis. 1997: 56:68–70. |
[ 14 ] | Shirazy K, Hajjaj-Hassouni N, Hammond C, Jones H, Ladjouze Rezig A, et al. The Prevalence of Non-radiographic Axial Spondyloarthritis among Patients with Inflammatory Back Pain from Northwest and South Africa: Data from a Noninterventional, Cross-Sectional Study. Rheumatol Ther. 2018; 5: 437-445. |
[ 15 ] | Kalidi I, Fofana Y, Rahly AA, Bochu V, Dehay C, Gony J, Hors J. Study of HLA antigens in a population of Mali (West Africa). Tissue Antigens. 1988; 31: 98-102. |
[ 16 ] | Ouedraogo DD, Tieno H, Kabore H, Palazzo E, Meyer O, Drabo JY. Ankylosing spondylitis in rheumatology patients in Ouagadougou (Burkina Faso). Clin Rheumatol. 2009; 28:1375–7. |
[ 17 ] | Lopez-Larrea C, Mijiyawa M, Gonzalez S, et al. Association of Ankylosing spondylitis with HLA-B*1403 in a West African population. Arthritis Rheum. 2002; 46:2968–71. |
[ 18 ] | Diaz-Pena R, Blanco-Gelaz MA, Njobvu P, Lopez-Vazquez A, Suarez-Alvarez B, Lopez-Larrea C. Influence of HLA-B*5703 and HLA-B*1403 on susceptibility to spondyloarthropathies in the Zambian population. J Rheumatol. 2008 ; 35:2236–40. |
[ 19 ] | Lebughe P, de Vlam K, Westhovens R, Mbuyi-Muamba JM, Malemba JJ. pondyloarthritis in the Democratic Republic of the Congo: a prospective hospital-based study. BMJ Open. 2018 ; 8 : e020329. |
[ 20 ] | Essouiri J, Abourazzak FE, Kona, Harzy T. Profile of Patients with Spondyloarthritis in Morocco. Curr Rheumatol Rev. 2018;14 :258-263. |
[ 21 ] | Navarro-Compán V. An Update on Diagnosis and Classification of Axial Spondyloarthritis. Current Rheumatology Reports. Curr Rheumatol Rep. 2019 Jun 15;21 (8):39. doi: 10.1007/s11926-019-0838-5. |