The concentration of CEA and Cyfra 21-1 in patients with non-small cell lung cancer treated with tyrosine kinase inhibitors
DOI: 10.54647/pm31142 75 Downloads 61429 Views
Author(s)
Abstract
Objective: The purpose of this study was to determine CEA and Cyfra 21-1 concentrations in plasma of patients with non- small cell lung cancer before and after three months, six months of treatment with tyrosine kinase inhibitors.
Methods: 400 patients with non-small cell lung cancer were first treated with tyrosine kinase inhibitors (gefitinib or erlotinib). Before and after three months, six months of treatment, the patients were evaluated the clinical symptoms, chest computed tomography and quantified CEA, Cyfra 21-1 concentrations in plasma.
Results: In patients with non-small cell lung cancer, CEA and Cyfra 21-1 data followed an abnormal distribution with the median of 18.94 (range: 1.79 – 1553.0) and a median of 6.52 (range: 1.51 – 590.0), respectively. There was a strong positive correlation between CEA and Cyfra 21-1 concentrations (r = 0.84). CEA and Cyfra 21-1 concentrations decreased after treatment with tyrosine kinase inhibitors but the difference was not statistically significant (p > 0.05).
Conclusions: CEA and Cyfra 21-1 are significant markers for diagnosis and follow-up in patients with non- small cell lung cancer treated with tyrosine kinase inhibitors.
Keywords
CEA, Cyfra 21-1, erlotinib, gefitinib, non- small cell lung cancer
Cite this paper
Tong Quoc Dong, Ho Thi Long, Nguyen Thi Thu Hien, Doan Vu Nam, Pham Thai Binh, Pham Van Tran,
The concentration of CEA and Cyfra 21-1 in patients with non-small cell lung cancer treated with tyrosine kinase inhibitors
, SCIREA Journal of Medicine.
Volume 5, Issue 6, December 2021 | PP. 62-74.
10.54647/pm31142
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