Synthsis of the acetals R1OCH2OR2 and R1OCH2OR2 by double alkoxylation of dichloromethane via “mini combinatorial” approach and their anticancer activity in the HeLa cell line
DOI: 10.54647/chemistry150291 93 Downloads 160004 Views
Author(s)
Abstract
The mixtures of two hydroxylic components (alcohols and phenols) reacted with CH2Cl2 in basic medium under the conditions of the solid-liquid phase-transfer catalysis to furnish the mixtures of three possible formaldehyde acetals separable under ordinary column chromatography. Using 7 phenols and 7 alcohols, 22 new acetals having the structures R1OCH2OR2 and ROCH2OR were obtained and screened for antiproliferative activity in the HeLa cell line. The compound 21 stands out as ca 15 times more active than doxorubicin.
Keywords
alkoxylation; anticancer activity; combinatorial chemistry; formaldehyde acetal; HeLa
Cite this paper
Maria Joselice e Silva, Erwelly Barros de Oliveira, Jaciana dos Santos Aguiar, Alexander Y.Nazarenko, Gilson Bezerra, Bogdan Doboszewski,
Synthsis of the acetals R1OCH2OR2 and R1OCH2OR2 by double alkoxylation of dichloromethane via “mini combinatorial” approach and their anticancer activity in the HeLa cell line
, SCIREA Journal of Chemistry.
Volume 8, Issue 1, February 2023 | PP. 16-26.
10.54647/chemistry150291
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